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Results demonstrating the global implication of K27M mutations and aberrant levels and distribution of H3K27me3 marks in pediatric brain tumors in specific regions further accentuate the core of this disease in the childhood years as epigenomic in nature (reviewed in [ 48, 65]).
Moreover, even though the global implication of E Coli is declining slightly, the proportion of E Coli that produce betalactamase (including extended-spectrum betalactamase) is increasing, as is the proportion of E Coli with reduced susceptibility to fluoroquinolones, as already reported [ 9].
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