7 Our findings are also consistent with findings showing that BDNF is affected at different levels in aged rats with global impairment, including reduced transcription, impaired protein synthesis and processing, and decreased activation of TrkB receptors.
In a study of 314 children referred to an ADHD diagnostic clinic, ADHD symptoms were only moderately correlated with global impairment as measured by a composite Global Impairment Index score, combining a number of parent- and teacher-rated competency scales of behaviors observed at home and school [ 5].
Correlational analyses revealed that MMSE scores were correlated with all three performance conditions suggesting that impaired praxis performance may relate to more global impairment.
Schizophrenia patients had a global impairment on the task but bipolar patients were only impaired on a recognition memory component.
In contrast, the alpha-1 selective positive GABAA receptor modulator zolpidem and the cholinergic receptor antagonist scopolamine only impaired odor span at doses that produced more global impairment, including decreased accuracy in the control discrimination and increased response omissions in the both the odor span and control discrimination procedures.
Dementia is a condition characterized by the global impairment of intellectual capacity.
The presence of a secondary task resulted in a global impairment of memory function.
According to wide literature, a global impairment in the temporal and spatial domains as well as an increased crowding effect is common of dyslexics.
Levels of UbG76V-GFP proteins were 2-fold higher in Het than in Wt mice, showing the global impairment of UPS in the heart of Het mice.
These findings suggest that poor insight in schizophrenia may be a function of specific prefrontally mediated neurocognitive deficits rather than a global impairment in neuropsychological functioning or different profiles of psychopathology.
The current study utilized a within subjects design (N = 107) to compare parent report of impairment on two versions of a global impairment measure: one that specified ADHD as the source of impairment (Impairment Rating Scale ADHD) and a standard version that did not (Impairment Rating Scale).
