Global identification of traits that share common causal transcripts and genetic mechanisms requires a reliable reconstruction of a global causal network among variants, transcripts and traits a notoriously difficult problem, particularly in the case of a large collection of traits and high throughput data.
Bertone, P. et al. Global identification of human transcribed sequences with genome tiling arrays.
This change to a global identification and a commitment to act accordingly has enormous implications.
The proposed technique consists of a local estimation phase and a global identification phase.
Unknown parameters are further deduced from a global identification procedure, based on limited feasible experiments.
Zik M, Irish VF. (2003) Global identification of target genes regulated by APETALA3 and PISTILLATA floral homeotic gene action.
In AIoT, we leverage the enhanced technologies of service oriented architecture, global identification and parsing, and electronic pedigree.
We have established an experimental pipeline in Caenorhabditis elegans that permits global identification of the binding sites for transcription factors using chromatin immunoprecipitation and deep sequencing.
Li L, Wang X, Sasidharan R, Stolc V, Deng W, He H, Korbel J, Chen X, Tongprasit W, Ronald P, Chen R, Gerstein M, Wang Deng X. (2007) Global identification and characterization of transcriptionally active regions in the rice genome.
Abstract: "Mass spectrometry-based proteomics enables the global identification and quantification of proteins and their posttranslational modifications in complex biological samples...Here, [investigators] demonstrate the feasibility of deep genomefree proteomics by using a reference proteome derived from heterogeneous mRNA data.
Next generation sequencing (NGS) analysis of DLBCL has facilitated global identification of numerous and diverse genetic abnormalities in these neoplasms and has shown that GCB and ABC tumours have different mutation profiles.
