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Their clinical relevance was confirmed through analyses of the global efficacy rating of the patients [83].
The global efficacy measure combining scintigraphy and RTOG score favoured the experimental arm (P= 0.07).
On the global efficacy question, 81.3% of patients showed improvement compared with 18.7% with placebo.
Efficacy was assessed by using the self-administered International Index of Erectile Function (IIEF), a 15-question validated measure of ED, and a global efficacy question (Did the treatment improve your erection?).
The surprisingly long survivals observed among subsets of 'molecular-selected' patients, treated with frontline EGFR tyrosine-kinase inhibitors (TKIs) in still limited prospective clinical trials, could herald significant improvement in the global efficacy of lung cancer therapeutics.
Postoperative pain outcomes included pain scores in 34, rescue analgesia in 36, time to first rescue analgesia in 15, pain on activity in eight, number of patients with pain in six, pain relief in three, global efficacy rating in two and analgesic consumption via PCA in four studies.
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In addition, both investigators and patients provided a global assessment efficacy at weeks 4 and 12 post-treatment.
These studies suggest that a wide and yet to be fully characterized range of molecular effects are induced by aripiprazole in the central nervous system, and allow the hypothesis that these effects may be more useful to explain the global therapeutic efficacy and long-term neurobiology of the compound beyond its receptor profile.
The following instruments were used to assess efficacy: Global Impression of Perceived Difficulties (GIPD), Attention-Deficit/Hyperactivity Disorder Rating Scale (ADHD-RS), Clinical Global Impression-Severity (CGI-S), and the Weekly Rating of Evening and Morning Behavior – Revised (WREMB-R).
In Table 3 the global assessment of efficacy and tolerability is referred as reported by patients.
Pain diagnosis of migraine was made according to the second edition of the International Classification of Headache Disorders (ICHD-2) criteria and pain relief was measured by the patient's global assessment of efficacy, using the Migraine Disability Assessment Questionnaire (MIDAS).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com