Sentence examples for global defect from inspiring English sources

Our findings indicate that the ichthyosis in SLS is associated with a barrier abnormality that is not only characterized by structurally defective SC lamellar membranes, but also by a global defect in LB formation and secretion.

It is a global defect of the market that lives on after the GFC.

However, RBP-J deficiency did not result in a global defect in M2 gene program as expression of Marco and Jmjd3, two prototypical M2-associated genes was not reduced in Rbpj cKO mice (Fig. 2B), indicating a restricted effect on M2 phenotype that is similar to the restricted effects of RBP-J deficiency on the M1 phenotype (Xu et al., 2012).

We found no global defect in Mer expression in lupus blood.

Apoptotic cells were present throughout the embryo, indicating a global defect in cell survival.

These data indicate that lack of IRF8 does not result in a global defect in reactive processes of microglia.

Quality of care was estimated by a global defect-free care measure, and individual performance measures within estimated risk score quintiles.

The global defects in T cell activation, effector function, immunoregulation, and lymphokine generation observed in CD4+ inducer lymphocyte deficiency emphasizes the central role that the CD4 T lymphocyte plays in the activation and regulation in vivo immune responses.

The workshop has also discussed the more global defects at the cellular levels such as in celiac disease, microvillus inclusion disease, or cystic fibrosis which also elicit chronic diarrhea [7 9].

Subsequent Southern analysis revealed that the selected strains displayed global defects in DNA methylation patterns.

Gfi1-deficient progenitor B cells show global defects in IL7Rα-dependent signal cascades.