Table 2 shows the baseline patient characteristics of the three subgroups defined by their global compartment cartilage volume loss; Table 3 shows the clinical data; and Table 4 shows the meniscal and bone change data.
For example, at 24 months, the percentage of cartilage loss in the global compartment with the volume method (licofelone mean ± standard deviation: -5.9 ± 2.2%, naproxen: -7.3 ± 2.5%, p < 0.0001) provided similar findings to those from the mean thickness method (licofelone: -5.4 ± 2.1%, naproxen: -6.7 ± 2.4%, p < 0.0001).
Moreover, given that intracranial contents within the rigid skull (blood, brain tissue, and cerebral spinal fluid) are nearly incompressible, constraints on cerebral vascular compliance by the global intracranial compartment compliance are to be expected (Hu et al. 2006).
Differential gene expression during early follicular development was selected with a FDR <5% for global 'intra-compartment' effect (nbinomGLMTest) and pval <1% for pairwise comparison (nbinomTest) with a fold change >2.
Furthermore, 6 motion parameters (realignment parameters: translation along, and rotation around, the x, y, and z axes) and 2 parameters which correct for global intensity fluctuations (compartment signal parameters: white matter and cerebral spinal fluid; Verhagen et al. 2008) were added as regressors.
These findings are in line with the calculation of the correlation coefficients between the changes over time of the two measurements, which are all greater than 0.90 (p < 0.0001, Pearson rho) regardless of the cartilage compartment (global, medial or lateral), the time span (6, 12 or 24 months) or treatment group chosen.
Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene expression.
This suggests that the functional capacity of NKG2A+CD57+CD56dim NK cells may not be directly affected on a per-cell basis, and that their decline may be associated with the functional capacity of the global CD56dim NK cell compartment.
Comparison of the medial compartment cartilage global volume with the medial minimal JSW obtained by radiographs at baseline revealed some correlation between the two measurements (r = 0.26, p < 0.001; data not shown).
The CS group showed significantly less cartilage volume loss than the placebo group as early as 6 months for the global knee (p=0.030), lateral compartment (p=0.015) and tibial plateaus (p=0.002), with significance persisting at 12 months.
Notably, individual mineralized and non-mineralized compartments differentially impacted the global properties of the multi-compartment composite.
