Sentence examples for global compaction from inspiring English sources

Local stabilisation by enlargement and reinforcement of the folding nucleus, global compaction by the addition of salt and non-native interactions are shown to contribute to the observed deviation from the two-state behaviour.

We show a link between transcription and large-scale chromatin packaging independent of the bulk 30 nm chromatin fiber and propose that transcription, not the global compaction of 30 nm chromatin fibers, determines the cytological appearance of large-scale chromatin structures.

This global compaction of chromatin fibres could therefore protect the genome from subsequent damage.

To address whether a change in global compaction can be attributed an alteration in HP1 levels we Western blotted for HP1α and HP1β after DNA damage.

Our extended observation period up to day 10 upon differentiation revealed the distinct global compaction of the Xist RNA-defined Xi territory towards a Barr body typically at day 5.

Genomic studies mostly provide one-dimensional information encoded in DNA, but we cannot ignore the fact that in eukaryotic organisms, DNA is packaged into chromatin structure, where DNA folds to a global compaction of at least 104 [ 1].

Previous studies have proposed LOX binding to histone H1 in vitro, and histone H1 is known to control global chromatin compaction and mitotic chromosome architecture.

In essence our work eludes to the regulation of the histone code by a GPCR [52], which accounts for many chromatin functions, including transcriptional regulation through cis-acting (local and global chromatin compaction), as well as transacting (recruitment of transcriptional activators and inhibitors) mechanisms of epigenetics [53].

The existence of these protein complexes also raises the interesting possibilities that, in proliferating cells, condensins interact with chromatin-remodeling complexes to coordinate cell-cycle progression and/or transcriptional regulation to changes in global chromosome compaction states.

Notably, the impact of H2A.Z on global gene compaction is less than either H3-K56Ac or Ssu72, consistent with the correspondingly weaker transcriptional defects due to loss of H2A.Z.

However, very weak, nonspecific interactions between the N-terminal and C-terminal regions are reflected in a slight decrease in the global electrostatic compaction of the protein, as indicated by a small ∼1.5% decrease in the rate of translational diffusion upon acetylation of WT aS.