Sentence examples for global alterations from inspiring English sources

Global reduction in DNA methylation and global alterations in histone PTMs have been identified as general features of neoplasia [12], [13], [14], [15], [16].

In this work, we have examined the cellular and molecular basis of an extremely pleiotropic phenotype of CP-r cells that creates global alterations in gene expression resulting in altered expression of cell surface protein and decreased endocytosis.

The challenges resulted in large global alterations in transcriptional activity, with 2363 genes being significantly altered following infection compared to 959 genes that were altered by the starvation, indicating that 23.9% and 9.7% of those genes that passed filtering were significantly affected by these treatments.

PKA might be most practical as a therapeutic target in disorders with global alterations in cAMP PKA activity due to genetic or environmental factors.

Accumulating evidence points to the direction that global alterations in nuclear architecture and chromatin folding conspire with unstable epigenetic states of the primary chromatin fiber to drive the phenotypic plasticity of cancer cells.

We explore a generic bi-ventricular heart model in response to volume- and pressure-overload to demonstrate how local changes in cellular morphology translate into global alterations in cardiac form and function.

First, we show that deletion of Rspo1 results in global alteration of muscle regeneration kinetics following acute injury.

Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture.

Pain progression has been evaluated in MOH patients, suggesting the presence of a global alteration in the processing of noxious stimuli throughout the pain matrix and the occurrence of significant functional changes in the lateral pain pathway [28].

We have previously shown that acute application of simvastatin on human skeletal muscle samples induced a cascade of cellular events originating from mitochondria and resulting in a global alteration of Ca2+ homeostasis.

We found that the reduced number of D4Z4 repeats in FSHD myoblasts was associated with a global alteration of the three-dimensional structure of the 4q35 region.