Of the QTL reported so far, the one on 3BL consistently gave the largest effects and was identified from several genotypes [ 9– 11].
Turning to the residues giving the largest effects, Pro39, Val40, and Gly41, we found that the rate reduction due to mutation of each of these residues was considerably smaller in the D38E background than with the WT Asp general base, suggesting that each of these residues plays a role in positioning the general base for catalysis.
Given the large effect on our focal species, Pseustes likely affects other understory nesters, a topic warranting further study.
Given the large effect on integrin activation compared to the smaller effect on spreading, however, the balance of these appears to favour increased thrombus size in PKCθ−/− platelets.
4) Given the large effect of Wnt4 knockdown, the redundancy argument is not strong.
Analysis: Given the large effect of the X chromosome it seems critical to include X variants in the covariance matrix.
The magnitude of the differences observed that is attributable to diabetes might be expected to be reduced given the large effect of smoking.
In terms of revising, the following major points need to be addressed: Analysis: Given the large effect of the X chromosome it seems critical to include X variants in the covariance matrix.
Given the large effect on endogenous Bax by parkin, we measured the mRNA levels of Bax by qPCR, using the HEK-ParkinM2 clone that expressed the highest levels of parkin and had the greatest effect on Bax protein levels.
Given the large effect of feeding status, we again separated the fed from the fasted values and identified treatment effects largely confined to the fasted groups and showing sex differences (treatment × sex, p < 0.04).
