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Importantly, the discovery gives a mechanistic explanation of how the Notch activity is augmented in gliomagenesis.
The discovery here of the HIF-1α/HIPK2 circuitry gives a mechanistic explanation of the p53 apoptotic inhibition in response to drug under hypoxia in those tumors that retain a not functional wild-type p53.
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We showed that the threshold concentration is shared by toxicants with the same mode of action, which gives a mechanistic explanation for the observation that toxic effects in mixtures may occur in concentration ranges where the individual components do not show effects.
While our experiments establish that the non-catalytic head in combination with Kar3 determines the velocity of the motor complex, we indeed at this point cannot give a mechanistic explanation for the role of the "K-tail".
The present results give a mechanistic explanation to the already reported antiparkinsonian activity of KW-6002 [28], [28] and suggest that SCH-442416 could be useful in dyskinetic disorders, obsessive-compulsive disorders and in drug addiction.
Here we give a mechanistic explanation for this finding.
We provide a mathematical model for flagellar motor switching and its sensory control, which is able to explain all tested experimental results on spontaneous and light-controlled motor switching, and give a mechanistic explanation based on synchronous conformational transitions of the subunits of the switch complex after reversible dissociation and binding of a response regulator (CheYP).
This finding is consistent with the lipid sink theory as a mechanistic explanation of lipid rescue.
A mechanistic explanation of this effect of inter-specific competition is still missing.
The result is a mechanistic explanation of the mechanism's capacities.
This provides a mechanistic explanation of the regulatory effect of FE65 Ser phosphorylation on APP processing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com