For any given variant or gene, MARRVEL displays information from OMIM, ExAC, ClinVar, Geno2MP, DGV, and DECIPHER.
We demonstrate the existence of a striking negative correlation between the aggregation propensity of a given variant and the oxidative stress it elicits.
Having calculated the equivalent stress and the rate of equivalent creep strain, the condition of fuel rod cladding failure used on the basis of the energy version of the theory of creep gives us a criterion to decide if a multiple cyclic power change operating mode is permissible for a given variant of power history and coolant conditions.
Analysis of variance (ANOVA) was applied to verify whether means from independent experiments within each given variant were significant at level P < 0.05.
The subsequent header row contains a problem name and a number of workers appearing in the given variant of the environment.
Using in silico models, namely PolyPhen-2 (Polymorphism Phenotyping v2), SIFT (Sorting Intolerant From Tolerant), and LOFTEE (Loss-Of-Function Transcript Effect Estimator), ExAC estimates the impact of a given variant on protein function.
Reliably predicting whether a drug candidate is likely to be an HLA binder at a given variant constitutes a potentially valuable knowledge in evaluating the likelihood of an associated ADR event in a subpopulation of patients.
Finally, starting from the focal sample plots, adjacent grids were spatially merged to each sample plot only if (i) their values were inside earlier computed delineation thresholds for the given variant (dynamic, 5%, 10 %, 20), and (ii) adjacent pixels that met the first assumption could create spatially constant polygons.
All mice infected with a given variant were housed together in an autoclaved, polycarbonate filter-top cage inside a laminar flow hood.
PCR primers were designed flanking approximately 200 bp of a given variant and sequenced on an ABI 3730 capillary sequencing instrument following standard procedures (Life Technologies).
As gonad development in males and females involves distinct genes and pathways, a given variant might disrupt one gonad specific pathway, leading to DSD, whilst having no effect on the development of the other gonad type.
