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Given this difficulty of thoroughly exploring the chemical-space of drug like molecules, fragment-based approaches have emerged.
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Given this difficulty and the purpose of this study, to examine whether different computational methods would generate consistent results on expression conservation, the performances of Liao and Zhang's method, Dutilh et al.'s method, ICC and Essien et al.'s method were evaluated based on their pair-wise agreements.
Given this difficulty, we consider the construction of outer identified sets (i.e. supersets of the identified set) that are easier to compute and can still characterize the parameter of interest.
Given this difficulty, the aide said, an extension of the Nov. 23 deadline would not help because "time is not the enemy here".
Given the difficulty of this estimation problem, I anticipate that full-likelihood methods that can leverage all of the information present in the sequence data will become increasingly important for robustly estimating shared evolutionary history across taxa [ 45].
Given the difficulty of this move, try it at a slow pace at first until you get the hang of it.
Other tyre companies regard this as "brave", given the difficulty of doing business in Russia.Pirelli will not yet touch India: the market for premium tyres is tiny, and the wheel sizes of commercial trucks and of the Tata Nano (a super-cheap car) are too small, says Mr Gori.
The nearest of the islands, off the westernmost tip of Ireland's Dingle Peninsula, is but two miles from shore, but it may as well have been two thousand given the difficulty of traversing this chasm through rainstorms, sea fog, and wintry gales.
Bystander cell killing is essential for the clinical success of this treatment strategy, given the difficulty of achieving 100% efficient gene delivery in vivo using current technologies.
Given the difficulty of extracting this data without individual chart reviews, we applied the multiplier to all patients in the cohort.
Given the difficulty of conducting this type of research, it is essential for future research, even when conducted on small samples, to maintain a controlled design and standardized methods of outcome evaluation.
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