Sentence examples for given this difficulty from inspiring English sources

Given this difficulty, the aide said, an extension of the Nov. 23 deadline would not help because "time is not the enemy here".

Given this difficulty of thoroughly exploring the chemical-space of drug like molecules, fragment-based approaches have emerged.

Given this difficulty and the purpose of this study, to examine whether different computational methods would generate consistent results on expression conservation, the performances of Liao and Zhang's method, Dutilh et al.'s method, ICC and Essien et al.'s method were evaluated based on their pair-wise agreements.

Given this difficulty in DNA isolation from the soil samples, enrichments of sulfate reducers and MTs were attempted from the Sages site soil as a means of verifying their presence and thus the potential for TCE transformation activity at the site.

Given this difficulty in predicting gene start sites and 5′ UTRs, we excluded the majority of cis-encoded sRNAs from further study, except for candidate sRNAs (e.g. BTH_s13 and s19) that were characterized by a single peak upstream from a gene with little or no expression.

"I have told my collaborators that in the next 40-50 years it is very unlikely people will be so foolish as to repeat this experiment, given the difficulty I ran into," Prof Ting told BBC News.

Given the difficulty of this estimation problem, I anticipate that full-likelihood methods that can leverage all of the information present in the sequence data will become increasingly important for robustly estimating shared evolutionary history across taxa [ 45].

Given the difficulty of this move, try it at a slow pace at first until you get the hang of it.

St Agnes, Scilly I count this fickle stretch of sand as the southernmost in Britain - and given the difficulty in reaching this corner of the kingdom, you can expect to enjoy the place in relative solitude.

Given the difficulty in conducting this type of research, it is not surprising that this remains a considerable – but important – gap in the literature.

Third, as the sources of data in this study were routine clinical databases, reliability of data completion in the clinical practice cannot be assured given the difficulties this task sometimes involves in this setting.