Given these thermodynamic restraints, the observations that multivalent arsenicals remain effective inhibitors of oxidative protein folding of reduced RfBP, even in the presence of 5 mM GSH, suggests that they bind with subnanomolar Kd values to the reduced protein.
"Copenhagen is highly involved in these programmes and took a transparent decision that the young animal in question could not contribute to the future of its species further, and given the restraints of space and resources to hold an unlimited number of animals within our network and programme, should therefore be humanely euthanised".
We constructed a female and male equivalent of each core case (where possible, given the restraints of the FRE and the individual and absolute risk levels defined above).
Given the restraints due to high costs of orthodontic services and lack of publicly funded dental treatment programs in these countries, it becomes increasingly important to recognize the need for orthodontic treatment according to the severity and to identify modifiable factors that can be addressed through preventive and interceptive orthodontics [ 17].
However, given budget restraints and the need to minimise response burden for participants, it was necessary to limit the total number of survey questions.
Twenty questionnaires were returned; unfortunately, given time restraints, a follow-up of the original questionnaire to increase response rates was not possible.
Disvis takes as input two atomic structures and a file with distance restraints, and outputs the sum of complexes complying with a given number of restraints together with a density showing the maximum number of consistent restraints at every position in space.
"Given the budget restraints we're forced to plan for, we have to help the city's neediest and most vulnerable families first".
I spent a large part of my working life analysing town water supply pipe networks using computer algorithms that I had written myself, and the ultimate algorithm for me would be one that completely designs the cheapest network for given restraints, particularly the minimum water pressure at any node of the network at any time of day.
A scaler was used to remove any remaining plaque, although given clinical time restraints this was occasionally difficult to achieve.
