The phrase "given these difficulties" is correct and usable in written English.
It can be used to introduce a statement or conclusion that takes into account the challenges or obstacles mentioned previously.
Example: "Given these difficulties, we must reconsider our approach to the project."
Alternatives: "Considering these challenges" or "In light of these issues."
Given these difficulties, EMU supporters will be disappointed that the government did not announce more concrete measures to promote convergence.
Given these difficulties, Grossman's version is remarkably lucid, and her lines often achieve a mesmerizing shimmer that would surely have pleased her subject.
Given these difficulties, it's tempting to replace Wordsworth's salute to youthful vitality with the 29-year-old Bon Scott's less optimistic observation: "If you wanna be a star of stage and screen / Look out, it's rough and mean".
Given these difficulties, investors may instead be most likely to react to how other investors are reacting, meaning that negative sentiment could feed back upon itself, causing extremely rapid changes in prices.
Given these difficulties, did the U.S. government set itself up for failure by presenting the recent wars to the public in such personal terms, as a response to the actions of a few bad men — declaring war first on Osama, and then on Saddam?
Given these difficulties, it can be hard to say much that is useful about international coercion.
Given these two difficulties, our approach to the experimental design problem may be seen as an example of establishing an exploration/exploitation tradeoff [6], and is a high-dimensional analogue of the technique known as Kriging in geostatistics [7].
Given these communication difficulties [ 6], several telemedicine approaches have been tried out in recent years.
Given these known difficulties, it seems reasonable to interpret the faint and variable plastid GFP fluorescence observed herein as evidence of dual targeting.
Given these potential difficulties in pediatric HIV care, it is necessary to demonstrate that successful treatment of HIV-infected children in resource-limited settings can be achieved (1).
Given these logistical difficulties, and following from the traditional view that natural selection is a powerful force (Endler 1986), a frequent default has been to infer adaptive evolution based simply on evidence that mean phenotypes have changed in ways that intuition suggests are adaptive.
