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Given their specificity for type 1 diabetes [ 6], however, this does not detract from their well established value, in combination with other autoantibodies, in assessing risk of the disease [ 6, 10, 20], but does illustrate how useful biomarkers need not necessarily have associations with genetic markers that confer susceptibility to disease.
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Given their broad specificity, they appear to be ideal therapeutic agents.
Nuclear medicine Tc-99m MDP bone scans are of limited value given their low specificity [38].
The number of target genes was markedly reduced in the clusters of sporadic trans-factors, as expected given their greater specificity.
Qualitative assays do seem to be more efficient (notably in low prevalence populations, see table 6), which is not surprising given their higher specificity (fewer false positives).
These proved to be of little use given their lack of specificity for nervous tissue injury.
Given their apparent host specificity, it is highly likely that human infections by avian STs are of zoonotic origin.
Given their lack of specificity, these reagents can be used judiciously in cell biology and in in vivo studies to rule out a role for ASM if the results are negative.
An alternative possibility is that compensatory expression of MuRF1 or MuRF2 may be occurring in the MuRF3−/− hearts, given their overlapping substrate specificities.
Provided our hypothesis on their substrate specificity towards both proteins and PG would be true, these promiscuous GTs (PBP1B, PBP2A, PBP1A and MurG) are unlikely to be the priming GTs of their putative protein substrates, given their well characterized specificities towards PG precursors in both Gram-positives and negatives [ 70].
Given their subject and title specificity, they have been organized chronologically in this subseries to facilitate their discovery.
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