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Given the unfavourable climate, "all [public] funding agencies and most private agencies exclude research on human lines," says Elena Cattaneo, head of the Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases at the University of Milan, where Papadimou also works.
However, current breeding objectives are indirectly affecting adaptation given the unfavourable correlations between resilience and production traits (e.g. West, 2003).
Given the unfavourable health outcomes associated with sedentary behaviours, there is a need to better understand the context in which these behaviours take place to better address this public health concern.
With a median follow-up of 33 months, we found encouraging local control and overall survival rates (estimated 5-year LC 72%, and 5-year OS 74%), especially given the unfavourable patient selection (median tumor volume 1146 ccm and surgery with negative margins possible in only 22% of the patients).
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Further on, when the MGH approach was tested in a multi-institutional setting (RTOG 9514), toxicity was even higher and outcomes were clearly worse than expected from the MGH experience [ 22], although the results continued to compare well with historical data given the highly unfavourable group of patients included.
That may be just as well, given the spate of unfavourable publicity Three Gorges has received of late.Zhu Rongji, who in 1998 replaced Li Peng as prime minister, has been less enthusiastic about the project.
Given the scarce and unfavourable data on the validity of this system, we believe that it should not be used at present, especially not in a medical intensive care unit setting where supra-ventricular arrhythmia is common.
Given that the unfavourable outcome in patients with surrogate consent is often due to their initial clinical state (rather than inclusion in a trial per se), the issue of the family's feelings of guilt (and how to avoid these feelings) should be further addressed.
Given the higher obesity indices, unfavourable lipid profiles would have been expected among the migrants [ 21].
If the point of a biomarker based test is to use it to discriminate prognosis, clinicians need to know the probability that the outcome will be favourable or unfavourable given the test outcome.
Given the challenges and resources required to perform a surgical RCT, it would be unfavourable to forego a sample size calculation at the risk of under-powering a trial and reaching an equivocal conclusion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com