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MMR concordance rates of 91% are considered optimal given the technical limitations of current technologies (95% limit of agreement within plus or minus 2.5-fold for each method).
Given the technical limitations of the day, it had to be spread over all four sides of a pair of 10-inch 78rpm discs, and perhaps the inevitable discontinuity of the listening experience lay behind the mixed critical response it provoked in usually sympathetic quarters.
Given the technical limitations of the time, it would have been difficult to record the sound cleanly in most of the extremely wide shots Leone frequently used.
However, this is not possible given the technical limitations of these methods.
Given the technical limitations at their time of study, an EST approach would possibly identify only cDNAs which are abundant in PGT.
The use of this "archipelago" model is understandable given the technical limitations of earlier microarray technologies and the gene absence/presence calling criterion, which tended to bias the analysis towards identifying blocks of consecutive absent genes.
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Given the inherent technical limitations of ER, EFTR is a long-awaited dream of all endoscopists: a technology that potentially eliminates the technical challenges currently associated with cleavage of the intramural layers and expands the indications for ER to include diseases arising from the deeper layers.
Given these technical limitations, discerning the actual biological effects from experimental noises is challenging.
Given the intrinsic technical limitations to accurately compare copy numbers of different mature miRNAs, we think it is the most appropriate to leave this out for our manuscript.
Given these technical limitations, we have responded to this concern by moderating the language in the first section, stating now that "…in the absence of direct evidence of heterochromatin localization via cytology or ChIP-seq, we can only tentatively conclude that HP1E acts directly on this genome compartment" (subsection headed "HP1E encodes a spermiogenesis-restricted chromatin protein").
Given these technical limitations and its invasiveness, intravascular Doppler is not currently applicable to critically ill patients even in the setting of a research protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com