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Other combinations with strong theoretical and preclinical support include combinations with anti-cancer cellular or DNA vaccines, and combinations with small-molecule inhibitors (notable given the successful development of mutant BRAF and MEK inhibitors).
Given the successful development of tyrosine kinase inhibitors (TKIs) that target the epidermal growth factor receptor (EGFR) for the treatment of individuals with lung cancer positive for EGFR mutations (Paez et al, 2004), the identification of other kinases implicated in lung cancer would be expected to facilitate the development of new molecularly targeted therapies.
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Nonetheless, the successful development of a cancer center meeting international standards in a developing country should give encouragement to many working to address the pressing health needs in developing countries.
His collaboration with Count Antonio Giansanti Coluzzi, a model train collector, resulted in the successful development of Aster gauge one steam locomotives, which for 30 years have given enormous pleasure to model railway enthusiasts.
This is particularly challenging in South Africa given the range of issues affecting nutritional outcomes – but a challenge that needs to be addressed for the successful development of urban areas.
By contrast, look east to Asia, the successful development of those countries has transformed them from countries to which we gave aid, to countries with which we trade.
The successful development of a person can be like that of a successful poem.
The successful development of a separator by jellifying the electrolyte using polyvinyl alcohol is reported.
Capillary spontaneous imbibition is vital to the successful development of shale reservoirs.
The successful development of ECC with low-cost PVA fiber is expected to greatly promote the field application of ECC in China and give the references for the professionals to develop ECC with the local PVA fibers.
Hadfield's manganese steel led the way in the successful development of alloy steels.
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