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Given the substantial rates of thyroid dysfunction in lithium-treated patients, thyroid parameters should be checked before lithium is instituted and then monitored after 3 6 months initially and then every 6 12 months.
Given the substantial rates of HGT observed in modern-day bacterial chromosomes, it is envisaged that ancient prokaryotic genomes must have been similarly chimeric.
Given the substantial rates of mental health problems and the common experience of pain in this age group, and the possibility of a shared neurobiological pathway for these disorders [ 21], the relationship between them has already been the subject of considerable research.
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Given the substantial error-rates in this process such support is indeed needed.
These estimated gains in minority graduation rates may seem small, given the substantial heterogeneity in graduation rates shown in Table 6.
Given the substantial nuclear genome substitution rate heterogeneity observed in previous analyses (Barker et al. 2008; Tang, Wang et al. 2008), we were surprised to find no rate heterogeneity between the Cleomaceae and Brassicaceae.
A further limitation is that we did we did not assess mortality between groups; several deaths will inevitably have occurred among patients lost to follow-up [12], and given the substantial difference in follow-up rates between groups, we considered that any mortality estimate would likely be subject to substantial bias due to misclassification of mortality among patients lost to follow up.
Given the substantial therapy costs and the considerable rate of side effects (especially skin toxicity), improved strategies for identifying responders are needed.
However, given the substantial needs of the families and children with asthma in this community, which already had one of the highest asthma rates in the country, we felt this effort was critically important.
Given the substantial benefit of adjuvant endocrine therapies in ER positive disease, strategies to minimise the false negative ER status call rate are of paramount importance to prevent patients being denied such effective therapy[34].
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