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Given the substantial increase in the elderly population, neither of these figures seems rash or out of proportion.
Given the substantial increase in AEs, generic alendronate may not be as well tolerated as brand alendronate.
Given the substantial increase in power and the reduction in false positive signals we recommend using our combined strategy rather than stand alone WGA.
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Given the substantial increases in precision obtained using k-NN with an optimised value for k, further results were compared using this non-parametric method to parametric models for prediction of the 300 Index.
Various explanations have been given for the substantial increase in numbers of youths as well as adults attending government-sponsored schools; social scientists tend to categorize the reasons for these enrollment increases as products of either conflict or consensus in the process of social change.
3 Given the substantial and rapid increase in older motherhood and the known medical risks, it is important to determine whether, and how, older motherhood is linked to child health and development beyond the fetal stage.
This body of research has important implications for public policy, especially given the substantial real-world increases in skilled migrants to more developed countries.
Lastly, given the substantial and well documented increase in quit success with the use of pharmacological support, these were also included in the intervention.
Given the substantial illness and death associated with P. jirovecii infection and the resources needed to manage these cases, the increase in cases is of serious concern.
However, we note that increased lipid droplet formation occurs in the presence of only trace quantities of C1-BODIPY-C12 lipid label – a quantity that is too small to give rise to the substantial increase in lipid droplets upon VPA treatment, thus suggesting a VPA-dependent regulation of existing cellular lipids to increase droplet size (rather than increased uptake) (Fig. 1).
The decline in expression is particularly striking given the evidence for the substantial increase in macrophage numbers.
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