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Given the lack of methodological novelty, I feel that more effort needs to be devoted to improve classifier performance and utility.
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Given the lack of consistent benefit and the poor methodological quality of the clinical trials included in this analysis, definitive recommendations regarding the use of this therapy cannot be made at this time.
Given the lack of consistent benefit and the poor methodological quality of the trials included in this analysis, definitive recommendations regarding the use of this therapy cannot be made at this time.
More research using robust methodological study designs is possible and is needed, given the lack of evidence to support current policy.
The direct implication of these methodological limitations is to challenge the interpretation of these validation studies given the lack of relationship between main study and validation participants.
Given the lack of var.
Additionally, the lack of methodological standards makes assessments and comparisons between levels of adherence difficult.
The study's main limitation is the lack of methodological and investigator triangulation.
The lack of methodological detail in the previous studies makes this difficult/impossible to resolve.
However, the lack of methodological and analytical detail is also a liability in some places.
A limitation in the use of Ki-67 is the lack of methodological standardization and a validated cut-off level.
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