Given the inflammation-inducing properties of PGN and its associated components, we hypothesized that peptidoglycan of B. anthracis has a role in the sepsis and death of the host that occurs in the infection.
The ability of PD to affect systemic inflammation has also garnered significant attention, given the role inflammation plays in the pathogenesis of CVD.
Given the pronounced inflammation-induced skeletal manifestations, we decided to investigate how lack of immune surveillance by Tregs in Sf mice affects bone.
Remarkably, given the skin-inflammation phenotype of skin-specific Casp8 knock-out mice (Kovalenko et al., 2009; Lee et al., 2009), Casp8 heterozygosity potently suppressed the inflammatory skin phenotype while leaving the systemic inflammation unaffected.
This was in contrary to the authors' hypothesis that higher adiponectin level would be associated with lower all-cause mortality given the anti-inflammation, antiatherogenic, and insulin-sensitizing properties of adiponectin.
Given the importance of inflammation in acute kidney injury and the relationship between vitamin D and inflammation, we sought to elucidate the effect of vitamin D status on acute kidney injury.
Given the relationship between inflammation and carcinogenesis, recent studies have addressed the role of TLRs in inflammation-associated carcinogenesis in various cancers including GC.
Given the role of inflammation in injury and progression to dysfunction via pro-fibrogenic mechanisms, strategies to attenuate inflammation are promising therapeutics.
Given the role of inflammation in the development and progression of prostatic disease, it has been suggested that inhibition of inflammation would decrease the risk of prostatic diseases.
Given the importance of inflammation in tumorigenesis and growing evidence of subtype-specific features in ovarian cancer, functional investigations will be important to help clarify the importance of inherited variation related to inflammation in ovarian carcinogenesis.
