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23 Furthermore, increased removal of old collagen is likely, given the increased expression of mRNA encoding the matrix-degrading enzymes MMP-2 (kDa gelatinase) and MMP- 13 (collagenase 3), which were also elevated in Achilles tendinopathy.
Given the increased expression of Adamts1 in aged DS patients and an increase in extracellular granules seen in aged Ts65Dn mice, it is possible that changes in ECM processing and abundance could become more apparent in the aged mouse.
Given the increased expression of MTNR1B in individuals at risk of T2D, the pathogenic effects are likely exerted via a direct inhibitory effect on β cells.
Given the increased expression of anti-inflammatory genes in the striatum and enhanced JNK activity in the substantia nigra of Pink1−/− mice, we were interested to test whether Pink1−/− mice showed abnormal expression of inflammatory and/or anti-inflammatory cytokines in the striatum.
Given the increased expression of the AR mRNA in CXCR7 knockdown cells, CXCR7 most likely modulates AR protein levels through post-transcriptional mechanisms in LNCaP cells.
Surprisingly, given the increased expression of thermogenic markers in Elovl6 KO mice, we determined a lower maximal thermogenic capacity in Elovl6 KO mice.
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Given the increased protein expression of NADPH oxidase in mdx muscle, we then investigated whether this would result in enhanced NADPH oxidase activity.
Given the increased levels of TLR2 expression in co-infected animals we hypothesized that this receptor may be a determinant of the increased severity of inflammation in this group and that TLR2−/− animals will exhibit attenuated levels of lesion severity and inflammation, in response to co-infection.
Given the increased availability of both SNP data and gene expression profiles in epidemiologic samples, investigating both cis and trans effects to characterize potentially functional elements in genomic regions identified by GWAS is an important area of research.
But the increases were seen as necessary, given the increased borrowing costs for Fannie and Freddie.
Given the increased competition, successful bands needed to look beyond simply selling records, McCabe suggested.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com