Or at least it's willing to give the fork a chance.
Give the fork a quick (but gentle) jerk upward to separate these strands from the rest.
Landward, you can find the vineyards and farms that have given the North Fork the somewhat hyperbolic moniker of Napa Valley of the East.
Can we assume the Gmail guy might be in a good position to noodle down on this, particularly given the Google Wave fork under way across town?
The factors g± quantify the effect of the helicase-fork interaction and the native duplex stability on the stepping rate; p open is the probability the fork opens given the base pairing energy and the destabilizing effect of tension (Johnson et al., 2007; Huguet et al., 2010).
Given the clear presence of such fork proteins in replication foci, the lack of clearly visible MCMs and Cdc45 within replicating foci creates a paradox in which MCM-Cdc45 complexes facilitate DNA unwinding while not seemingly localized directly at forks within replication foci.
Currently, it is unclear how these steps are integrated, but given the complexity of a replication fork, it is most likely that a large number of factors are needed to link the general replication machinery to the telomere-specific replication machinery.
This is where I go all chopstick happy and rarely (if ever) get forked at the table (because they know me) but if they do give you the fork, you'll need it to handle their deluxe soup dumpling.
Five minutes of replication corresponds to ∼180 kb DNA replicated for each fork, ample time to give the observed spatial separation of two independent forks.
Crimp the sealed edge with a fork to give the classic empanadilla finish.
