Sentence examples for given the essentiality from inspiring English sources
Given the essentiality of RNA structure in regulating gene expression, it is important to perform mRNA structure analysis from the perspective of evolution.
Given the essentiality of RNAP for transcription, it appears likely that mutations in rpoB will have multiple effects on Mtb physiology in addition to RIFR.
Though the magnitudes of these effects are moderate, they are likely significant in vivo given the essentiality of LpoB for PBP1B function under all conditions tested (Paradis-Bleau et al., 2010; Typas et al., 2010), including different salt concentrations.
This set of procedure generated a number of different resultant networks, each representing a "minimal" adjustment that can optimally reproduce the given gene essentiality data.
This missing reaction gives rise to the essentiality of fatty acids in the ω-6 unsaturated fatty acid pathway.
However, given that essentiality may evolve relatively fast (Zhang and He 2005), essential genes in mouse may not be essential in humans.
Here we address the rarely considered significance of 8-oxoG, such as its optimal levels in DNA and RNA under a given condition, essentiality for normal cellular physiology, evolutionary role, and ability to soften the effects of oxidative stress in DNA, and the harmful consequences of its repair, as well as its importance in transcriptional initiation and chromatin relaxation.
Given their essentiality for health, but toxicity at high levels, it is not surprising that BA synthesis is tightly regulated.
Any oxidative phosphorylation reactions or diffusion transport reactions that had not previously been added to the model are appended given their obvious essentiality.
Each cell-line was screened in triplicate and a Gene Activity Ranking Profile (GARP) score, with an associated p-value, was developed by Marcotte et al. [ 16] to reflect the essentiality of a given gene within a given cell-line.
The essentiality of a given gene was determined by calculating the maximal growth rate using FBA when fluxes through associated reactions were constrained to be zero.
