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Given the developmental defects exhibited in animals lacking functional AMPK, we performed experiments to assess the extent to which potential developmental defects caused by impaired AMPK function contribute to starvation sensitivity in adults.
Moreover, gametocytes are intimately linked to asexual parasites and decoupling P. falciparum gametocyte dynamics from asexual parasite dynamics is challenging, especially given the developmental time-lag of gametocytes and the sequestration of the asexual parasites that hinder accurate measure of density.
Age for completion was restricted to an 8-week window around 18 months given the developmental age-specific nature of the questions (Heron, Golding, & ALSPAC Study Team, 2004).
DOI: http://dx.doi.org/10.7554/eLife.08627.009 Given the developmental regulation of Myo15 splicing, we examined the localization of isoform 1 in cochleae at different postnatal ages.
These complex genetic patterns are to be expected, given the developmental pathways needed to form the ENS and the many molecules that guide this development.
Given the developmental expression of these miRNAs, they may have taken on roles particular to the development of the honeybee embryo.
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The plans have stirred controversy in Bangladesh, raising the issue of whether, given the complex developmental challenges the country faces, it can afford to consider the environment.
Given the dramatic developmental change in neural architecture supporting social function, positive and negative facial cues may influence attention orienting differently in relatively young or old individuals.
We decided at the outset of the analysis to examine each of the three target grades separately, given the different developmental stage of each grade, the different rewards offered and the different outcomes of interest.
For many keen observers of biomedicine, the question is not whether Singapore should invest in the life sciences, but whether Singapore can afford not to invest, given the intense developmental plans by its regional competitors.
Given the substantial developmental defects described above, the subtle and limited changes in the gene expression profiles of E2f4 null tissues is nevertheless surprising, despite the largely normal physiology of these mice in adulthood.
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