Sentence examples for given the demonstration that from inspiring English sources
Given the demonstration that vaccinia-specific antibodies are both necessary and sufficient to confer protection against virulent monkeypox challenge in non-human primates [66], our finding that levels of MVA-specific NAbs may be driven predominantly by input viral antigens should help inform our understanding of the mechanism by which next-generation smallpox vaccines elicit protection.
Given the demonstration that at pH 8 metabolic energy optimizes efflux, the activity of varying concentrations of this agent at pH 5 and 8 on the efflux of EB after the fluorochrome has accumulated in the absence of glucose has been studied and the results obtained described by Figure 3 for the AG100TET that over-expresses its AcrAB efflux pump [5], [25].
Given the demonstration that Hig2 is secreted, these structure most likely correspond to overexpressed Hig2-EGFP in transit through the endoplasmic reticulum and golgi apparatus.
route, an important consideration given the demonstration that long-term sterilizing immunity is rarely observed when memory CD8+ T cells fall below a certain threshold (Schmidt et al, 2008).
Given the demonstration that energy-restricted diets can reduce PYY levels, the ability of DAIRY/CA to prevent this decline and result in a modest increase in PYY levels may be important for appetite regulation during weight loss.
Given the demonstration that SAM binds in proximity to, and even coordinates, the [4Fe 4S] clusters of radical SAM enzymes, it is clear that the redox potentials of the iron sulfur cluster and of SAM cannot be considered in isolation.
Despite this protocol difference however, the present studies provide construct validity for the 5C-CPT as a test of vigilance that parallels human CPTs, given the demonstration of a vigilance decrement that is unaffected by bias or strain differences in levels of vigilance, as well as reaction time differences that correspond to increases in attentional loads [41].
These studies are critical given the recent demonstration that increased expression of the endogenous calpain inhibitor calpastatin dramatically slows disease progression in JNPL3 mice (55), which may identify an effective therapeutic strategy to prevent PSD95 cleavage and block tau-mediated synaptic dysfunction.
Given the recent demonstration that expression of negative immune regulator Tim-3 is increased on exhausted T cells in patients with HCV [9] and that galectin-9 is a ligand for Tim-3 [7], we analyzed the circulating levels of galectin-9 in the plasma from patients with chronic HCV, non-viral liver disease and normal controls.
Given the above demonstration that the i-CDK9-induced MYC transcription occurred under the same conditions that stimulated the transfer of P-TEFb from 7SK snRNP to BRD4, it is important to confirm that BRD4 is indeed required for the MYC induction.
Given the present demonstration that WFS1 is also localized in the ER of layer 2/3 pyramidal cells in the mPFC and that Wfs1 deletion from these neurons leads to abnormal behavioral responses to stress and hyperactivation of the HPA axis, we were interested in assessing functions of PFC neurons that might be altered in response to loss of Wfs1.
