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Given the current burden of obesity and related chronic diseases in Baltimore City -- ranked dead last among Maryland counties in overall health outcomes, according to County Health Rankings -- it is a surety that our city will experience a disproportionate share of these avoidable costs.
However, given the current burden of evidence suggesting better recovery with CRRT as the initial therapy, physicians should seriously consider moving away from potentially deleterious therapies before proof of their non-inferiority is established.
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9 Given the current global burden of asthma, 10 if paracetamol is a cause of asthma its use needs to be urgently re-evaluated, particularly in the first two years of life during pulmonary development.
J. Michael Reed at Tufts University, who had no role in the critique but is a friend of Dr. Elphick, said that he had been impressed by the original Science paper but that given the current dialogue, "the burden of proof is to demonstrate that it's an ivory-billed woodpecker, and I don't think they've done it".
Given the current and growing burden of AHFS, there exists a substantial unmet need for novel therapies that improve outcomes.
Given the current demographic transition, the burden of T2DM and of diabetes associated co-morbidities will pose an increasing challenge to the health care system.
Given the current aging population and the rising burden of chronic disease and frailty, new patient-centred, comprehensive and interdisciplinary models of Acute Care Surgery are needed to optimize care in this vulnerable patient population.
Therefore, further research may be useful, but this needs to be balanced against the declining worm burdens worldwide and the absence of any good evidence of an effect given the current research.
Nationwide deployment of HPV vaccines to reduce the CC burden in Africa is more realistic than implementing a screening program, given the current failure of the national screening program due to logistic and funding challenges.
Given the current trends in demographic ageing, smoking cessation programmes should also focus on older people to curb the burden of smoking associated disease and mortality.
Given the current socio-economical and political context of Pakistan, this problem is expected to continue, which will only contribute to the burden.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com