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Given the constrains of limited exposure, this study attempted to demonstrate that dexamethasone, which is the backbone of most therapeutic regimens for multiple myeloma, reduces the plasma concentration of panobinostat, 40%% of which is metabolized by CYP 3A4 enzyme.
Given the constrains pose by time, and the relatively low rate of physician adoption of some clinical guidelines in general [ 10- 12], the extent to which GPs document recommended screening is not well understood.
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The navigation system becomes a key issue given the safety constrains of the heavy load to be transported in the complex scenarios, such as the reactor building.
Given the tight constrains in the definition, conserved TFBSs were scored in much smaller numbers than in the Clover analysis.
Converging studies support the notion that the motor system, after damage, generates the best functional motor output, given the anatomical constrains [ 32, 33].
Given the temporally constrained nature of the BOLD signal, fMRI studies are of limited value in this endeavour.
Given the tightly constrained promoter position relative to the TSS (usually between 7 to 10 nucleotides) promoter identification is straightforward once the TSS has been experimentally determined.
Given the highly constrained resources for health promotion, it is essential for decision makers to require information on the costs and cost-effectiveness of the interventions.
Many techniques have yielded insight into alcohol's effects on the organism, but perhaps the most challenging field, given the logical ethical constrains, is the study of the neuronal structures and mechanisms that are affected by alcohol and/or which play a role in the development of AD in living humans.
Pret's expansion programme has been remarkably constrained given the seemingly voracious appetite the UK public has for its food: customers graze on £100m of Pret products a year.
The last constrain, given the complexity and variability of must and wine composition, is not trivial and needs a considerable effort at both industrial and research levels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com