Some of these successful interventions have focused on improving visual information processing speed, which is not surprising given the considerable evidence that supports the role of processing speed in age-related cognitive decline.
Given the considerable evidence pointing to a contributory role for IL-6 in SLE pathogenesis, the a priori likelihood that therapeutic targeting of this pathway in SLE will be efficacious is high.
Given the considerable oral-facial phenotypes present in many ciliopathies, we wanted to explore the role of primary cilia during CNCC development.
"The time is not too late and it has not run out," said Bashar al-Assad, who is considered by many to be the heir apparent to his ailing father and who has been given a considerable role in Syrian affairs.
Obtaining a clear understanding of how each pathway contributes to substrate recognition by the proteasome is of considerable importance given the central role of the UPS in regulatory biology and the clinical significance of the proteasome as a target for cancer therapy [ 28, 29].
Given the central role of IL-1 signaling in inflammatory diseases, considerable effort has been devoted to the development of IL-1ra for clinical applications [ 17, 19- 24].
Given the critical role of RR in cell growth, there has been considerable interest in RR as a therapeutic target for cancer chemotherapy.
This is a considerable oversimplification, given the interacting roles of other hormones such as estrogens, arginine vasopressin, and cortisol (e.g., van Anders et al. 2011), but it serves as a useful and pragmatic first step in developing the connections of endocrine adaptations with the genetics, and epigenetics, of human risks and manifestations of disease.
Given the ambiguous role of DNA sequence in specifying centromere identity and function, it is of considerable importance to understand what contribution DNA sequence makes to chromatin structure.
However, this requires a considerable involvement from teachers, given the role they need to play in preparing for such mobility in terms of learning outcomes, learning activities and assessment.
