Thus, within the RuvC-like domain, Cas9 contains an almost 450 aa long insert which includes the HNH nuclease domain; nevertheless, the RuvC domain is most likely an active nuclease given the conservation of all four HJR motifs and the characteristic conserved secondary structure elements (Additional File 6).
All seed types have a higher fraction of conserved sites than one would expect by chance, given the conservation of their 3′UTRs (Supplementary Table S5).
Given the conservation value of the carbon stores and rich biodiversity residing in Xishuangbanna's natural forests, reducing rubber NPV only marginally would probably cost less than attempting to recover these resources.
Shark-like batoids within the Great Barrier Reef Marine Park (GBRMP) were chosen as a case study, given the conservation concern surrounding these species, limited knowledge of their spatial ecology and their exposure to fishing.
Given the conservation mission of the modern zoo, there is much discussion about how we might make zoos better to prevent an event like the one that led to Harambe's death.
Given the conservation importance of these species, there is current interest in determining if various recent human practices (land development, timber harvesting, road construction, etc).
While surprising given the conservation of these P-motifs and their known importance to Fra function [32], [33], the lack of P-motif specificity is consistent with our genetic rescue experiments.
Given the conservation of SET domain HMTs in vertebrates, zebrafish embryos may also carry these kinds of epigenetic changes during early development, in which the maternally deposited transcripts of SET domain genes are likely to play an important role.
Though we recognize the genetic circuitry in Drosophila may differ from that which exists in humans, we expect there to be substantial overlap given the conservation of gene function across species.
Given the conservation of the haplotype frameworks defined by fmSNPs across other out-of-Africa populations [9], these frameworks are likely haplotype backgrounds upon which more recent mutations having lower allele frequencies have been superimposed.
If silencing of the sole mouse X chromosome did occur, it is possible that the presence of the human X might compensate given the conservation of X-linked genes across mammals [21]; however selection might also have occurred to generate a silencing defective clone.
