The lack of information regarding associations with β-cell function, defined as the compensatory relationship between insulin secretion and sensitivity, is a particularly important limitation given the central role of this disorder in the pathogenesis of type 2 diabetes.
Given the central relevance of such interactions, it is important to note that a sample size of 180 000 rather than 110 000 would markedly enhance the capacity to study gene-environment interactions when the interacting determinants are both other than common.
Given the central role played by PDZ interactions in signaling and protein localization, it seemed important to revisit the issue of the PB "consensus" motifs and try to refine its current definition.
Given the central roles of marine diatoms in global primary production, marine food webs, and the biogeochemical cycling of important nutrients, there is much to gain in understanding how marine diatoms interact with their environment.
Given the central role of insulin resistance in the pathogenesis of T2DM and obesity, measures of insulin sensitivity are very important diagnostic and research tools.
Given the central role of histones and related proteins in a wide variety of critical cellular functions, we feel the need to continue to provide a centralized, curated source of important information on these proteins to the biomedical community.
Given the central role that diet has played in the adaptive radiation of snakes [ 7], venom thus represents a key adaptation that has played an important role in the diversification of snakes.
But that will give the central bank another headache.
The shakeup is meant to give the central government more scrutiny over the billion-dollar market.
Given its central importance in growth regulation, it is possible that the retention of many duplicates of major players in the IGF signaling system may play an important role in the continuous growth pattern of the teleost.
