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Using the existing drugs that induce autophagy is an option, but it has limitations given the broad role of autophagy in most cells, tissues, and organs.
Given the broad role of Arg in viral promotion and immune regulation our results may be significant for viral oncology more generally.
This type of treatment approach is problematic for DMD patients, however, given the broad role of this transcription factor, particularly in immunity.
Given the broad role of PHLPP in a wide spectrum of diseases, understanding its catalytic mechanisms is essential to its development as a therapeutic target.
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Parolin's remarks on the Irish vote are significant given the broader role Parolin plays in crafting the church's message on major diplomatic and social issues.
Given the broad spectrum of cellular roles played by this chaperone, the question arises as to whether Hsp90 global inhibition would be efficient in the treatment of OA.
Given the broad expression of FGFRs and their key role in development and physiology, toxicity issues are to be expected from FGFR inhibition.
However, given the broad target specificities of dasatinib, other tyrosine kinases may also have a role in the effects of dasatinib on chondrogenesis.
Her title in the White House will reflect the broad role she performed in the campaign.
Given its broad role during the healing phase after cardiac injury, additional research seems warranted before a therapeutic approach on Wnt to enhance cardiac regeneration can be carried out safely.
Given its broad role as a suppressor of inflammation, tissue injury and cell proliferation [6,7], PPARγ could represent a therapeutic target for PGI2 analogues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com