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Given that we excluded women who were physically active from the study, their sedentary behavior was not surprising, but still lower than expected.
First, the generalizability of the psychometric evaluation to the larger COPD and asthma population may be limited given that we excluded patients with unstable chronic medical conditions.
Likewise, given that we excluded women with health problems, and endeavored to represent the full range of SES (consistent with target communities' SES distribution according to census data), it is possible that levels of chronic stress or AL were different (e.g., lower) in the current sample relative to what might have been observed in other samples of Mexican-American women.
However, given that we excluded individuals reporting more significantly impairing comorbid disorders and findings that adult females with ADHD have higher rates of clinically relevant comorbid anxiety and mood disorders [ 83], we believe the underrepresentation of females in the sample mirrors the high-functioning, relatively comorbity-free adult ADHD population fairly well.
Nevertheless, and with full appreciation of these limitations, and given that we excluded subjects who replied that they did not know whether or not a first-degree relative suffered from AMD, we believe that our findings that self-reported family history of AMD is a risk factor for the condition are important.
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Given that we exclude the area close to the injection site from our analyses, we can also not exclude the possibility that changes of the layer 5 axonal arbors are within this area.
Given that we have excluded loci with high error rates, identified mis-labelled or mis-pedigreed individuals and re-scored individuals that cause mismatches or unlikely double recombination events, it seems reasonable to assume that the subsequent impact of typing error on map construction that we report is conservative.
To the best of our knowledge, this has not been described before, but could be due to sequence-dependent DNA methylation or the fact that genetic variation in a similarly methylated region can affect the entire region (given that we have excluded the direct effects of SNPs on methylation probes).
Given that S0102 excluded HER-2 overexpressing disease and accrued patients with relatively low prior anthracycline exposure and no prior taxane, it is difficult to find trials with similar populations for comparison.
25 Finally, our results may only be generalisable to singletons, given the fact that we excluded multiple births in our analyses.
Hillary remarked that "it's not too surprising that more than half of all peace agreements fail within five years" given that women are excluded from the negotiating table about 90% of the time (p. 572).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com