Sentence examples for given that the alterations from inspiring English sources

Given that the alterations displayed by the mtGenome demonstrate a field effect in breast tissue, there is merit in assessing NAF or DL recovered from women with both DCIS and IBC histopathologies.

Given that the alteration in greenhouse gas concentrations is the driver for the change, one expects the impacts to be highly dependent on the considered greenhouse gas scenario (GHS).

Given that minimal alterations of the histone H3 tail peptide drastically reduce its affinity for PHD HD1 complexes, we surmised that we might be able to identify small molecules that bind to these histone pockets and interfere with their binding to the histone H3 tail.

Given that alterations in the Kirrel3 gene are associated with autism and intellectual disabilities, this work provides the first insight into cellular mechanisms that may underlie Kirrel3-dependent neurological disorders.

Given that neurexin alterations were first discovered in autism and schizophrenia in 2006 (Friedman et al., 2006) and 2009 (Kirov et al., 2009), respectively, and further associations have been found since then (Reichelt et al., 2012), limited research has been conducted to determine whether neurexin deletions result in behaviors associated with these disorders.

Given that alterations in retinoid signaling can affect the differentiation of squamous epithelia, it is possible that the increase in these squamous lesions may be due to a retinoid-deficient state induced by the alteration in retinoid homeostasis.

Given that alterations in cell cycle length have been implicated in cortical development and expansion (Götz and Huttner 2005; Dehay and Kennedy 2007), it will be important to directly determine the cell cycle length of marmoset neocortical progenitors and compare it with other, lissencephalic and gyrencephalic, primate and nonprimate species.

We consider that analysis of SRH that changes over time is the most appropriate analytical method for investigating the relationship between this variable and mortality, given that these alterations are frequent.

Given that these alterations were present at previously described hot spots, we further determined the mutation frequency in primary tumor samples using our PMBL cohort.

Given that this alteration could rupture the full-length pRb protein if located within the reading frame of RB1, two tumors (one harboring exons 18 23 duplication and one harboring exons 1 2 deletion) out of a total of seven tumors expressing resistance to epirubicin harbored alterations in RBI, contrasting none out of 16 tumors with stable disease or an objective response (P = 0.08).

Given that the magnitude of alteration in transcription levels following ND was a function of time, magnitude of change in transcription levels would vary in cells sampled at different time point after stress.