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Given that some trials showed that antioxidants, and particularly selenium, may offer some advantage in the most seriously ill patients, we compared studies of patients with higher mortality in the control group vs. lower mortality.
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Conclusion: Given that clinical trials of skeletal myoblast grafting for myocardial repair are under way, it will be critically important to determine if these cells beat after grafting in the heart.
Given that clinical trials exclude people at high risk of hypoglycaemia, the benefit may be even greater in real-world settings.
Given that clinical trials generally study a population that is not completely representative of the general population with colorectal cancer (CRC), it is entirely plausible that the rates we observed are reasonable for the general CRC population.
Given that clinical trials are considered the best way to provide evidence and related knowledge for guidance, it is necessary to design a high quality national observational study that is capable of addressing these issues.
Given that randomised trials of MET are unlikely to occur in the future, administrative data may provide a useful tool for building the evidence base for MET both at institutional and health network levels.
Given that trials are morality plays, he said, the dramatis personae are crucial.
Given that trials had differing lengths of follow-up, we performed a sensitivity analysis that censored all participants at 24 months.
Our pre-clinical findings are promising given that trials are ongoing in advanced breast cancer patients using fulvestrant in combination with the mTOR kinase inhibitor AZD2014 (ClinicalTrials.gov: NCT01597388).
Given that trials of aspirin for primary prevention have enrolled too few patients with diabetes, guideline panels have applied indirect evidence from other high-risk groups to formulate this recommendation (4).
Given that trials were not available for 40 to 50% of patients in other studies [ 7, 8], our result is intriguing, although the phase I trial setting is different in that trials are neither site nor stage specific, allowing patients to enter into any open trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com