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Given that interactions were found in the relationship between the frequency of MVPA and health status according to sex, the results are shown separately for males and females.
The prior implementation – using soft constraints and rewarding edges with prior support instead of penalizing those without – is well-motivated given that interactions in pathway databases are derived from different cell types.
(The random effect of age squared cannot be computed. Given that interactions with the quadratic age slope were not significant, we simplified the models by using interaction with linear age slope only).
Here we focus on the separate effects of diet and genotype given that interactions, indicating pathways that were differentially affected by diet depending on the genetic background of the fish, were discussed in detail previously [ 12].
One possibility would be that phosphorylation regulates Ska complex formation, but given that interactions among the three Ska proteins can readily be detected amongst recombinant proteins purified from E. coli it cannot be essential.
Given that interactions with other individuals are an important component of fitness, there may be more than one optimal behaviour depending on the behavioural predisposition of others in a population.
Similar(54)
Given that interaction results were novel, we used correction for multiplicity considering all possible combinations (12 × 12 = 144).
In this context, Loewe [ 7] proposed an evolutionary systems biology framework for arriving at a better understanding of molecular interactions, given that epistatic interactions between mutations are commonly observed.
Many different mechanisms may underlie suppressive drug interactions, but given that drug interactions are analogous to genetic epistatic interactions, synthetic rescues certainly appear as a very promising candidate to be explored.
Given that GlcCer interactions have been shown to stabilize α-synuclein oligomers, we can hypothesize that similar α-synuclein lipid interactions in the cytoplasm could have similar consequences.
Given that such interactions may likely depend on the number of molecules of each interacting species, new models taking into account quantitative biology will be required to understand network modulation and finally develop therapeutic interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com