Sentence examples for given that alterations from inspiring English sources

The main focus in ADHD literature has been on dopamine related genes, given that alterations in dopamine neurotransmission is a core feature of ADHD [ 94].

Dopaminergic genes are candidate genes in TS studies given that alterations in dopaminergic neurotransmission are believed to contribute to the etiology of tics.

The results are relevant in regard to these indicators, given that alterations in the lipid profile are recognized as an important factor in cardiovascular risk among the overweight and obese pediatric population [ 44].

178– 181 Given that alterations in axonal transport have been observed in PD models, these beneficial effects are likely to occur also via inhibition of HDAC6 – although HDAC6 has yet to be tested directly.

Given that alterations in retinoid signaling can affect the differentiation of squamous epithelia, it is possible that the increase in these squamous lesions may be due to a retinoid-deficient state induced by the alteration in retinoid homeostasis.

Given that alterations in the Kirrel3 gene are associated with autism and intellectual disabilities, this work provides the first insight into cellular mechanisms that may underlie Kirrel3-dependent neurological disorders.

The network displayed in Figure 1 clearly reveals the massive scale of influence that cigarette smoke, as an environmental variable, exerts over the lymphocyte transcriptome; however we are unable to determine which genes are directly influenced by smoke exposure, given that alteration of the expression level of one gene can alter the transcription of other genes in these networks.

First we focused our attention on T leukemic Jurkat cells, given that alteration of mitochondrial potassium influx in these cells significantly impacts cell survival.

This was an unexpected finding, given that structural alterations to the efferent synapse as a consequence of α9 gene ablation have been described as early as P3 [13].

Given that these alterations were present at previously described hot spots, we further determined the mutation frequency in primary tumor samples using our PMBL cohort.

We consider that analysis of SRH that changes over time is the most appropriate analytical method for investigating the relationship between this variable and mortality, given that these alterations are frequent.