Sentence examples for given that addition of from inspiring English sources

Given that addition of SAM blocked methotrexate enhancement of BIO-induced β-catenin protein accumulation, we questioned whether aberrant methylation may impact expression of GSK3β or other members of the destruction complex.

Given that addition of basal insulin to previous OHA has been recommended as the way to initiate insulin therapy in type 2 diabetes (14, 15), one would expect to find studies comparing "intensification" of insulin therapy by use of prandial injections or replacing basal insulin by premixed insulin.

Moreover, UPR activation appears to depend on the reduction of protein glycosylation given that addition of GlcNAc totally prevents transformed cell death, indicating that prolonged impairment of protein folding is able to switch UPR from a protective to a harmful mechanism, especially in glucose-addicted cancer cells.

However, its position is approximately 5 Å from C1 of the antibiotic in FosB Bc, and given that nucleophilic addition of the thiol proceeds via direct SN2 substitution to C1, the functional relevance of the conserved water in the active site of FosB has remained unclear.

9 Surprisingly little research has been carried out, however, to understand the pattern of insulin use in this elderly LTC population, given that the addition of a basal insulin to OADs is a recognized strategy for introducing insulin therapy. 1, 10 This study, one of the first of its kind, described basal insulin use and its associated outcomes among elderly LTC facility residents with T2DM.

Given that the addition of mammography to CE MRI did not result in any additional cancer detected in the BRCA1 group, the cost-effectiveness could only be computed for the comparison of CE MRI to mammography alone.

The double counting error incurred by coupling the two models is also likely to be smaller for other pollutants such as PM, given that the addition of PM10 exhaust and PM10 non-exhaust emissions are approximately 5 10% of NO X.

Given that the addition of the CHEX table produced a change in luminosity and contrast to the participants' interface when compared to the interface of the control condition a difference that could affect pupil dilation we used dwell time on the changing aircraft for assessing attentional processing during fixations instead of measuring the pupil diameter (Poole & Ball, 2006).

Given that the addition of bevacizumab to chemotherapy appears to improve PFS, and that dose-dense chemotherapy may improve efficacy, we considered that dose-intense CapOx with bevacizumab warranted exploration.

Given that the addition of pelvic boost treatment is not clearly beneficial in the literature; the routine use of a pelvic boost in consolidation WAR should be questioned [ 23].

Given that the addition of heterochromatin is generally expected to suppress variegation in a fashion that correlates with the amount of heterochromatin added (Dimitri and Pisano 1989), it was surprising to observe that while a few of the tested lines showed no variegation, several lines showed strong, yet contrasting PEV phenotypes.