Moreover, consistent activation of the neurons enhances the stability of branches that have strong synapses while concurrently inducing retractions of those that have weak synapses [25].
Furthermore, the antibody has been extensively characterized by immunogold investigations, where it gives strong labelling of GABAergic presynaptic profiles making symmetric synapses [32].
All three actors give strong, lively performances.
However, the SRR hypothesis predicts that for any specific strong synapse in a maintained trace, reactivation must sometimes induce LTP of that synapse.
However, those feedback loops do not require SRR, because SRR postulates greater reactivation and Ca2+ influx at strong synapses, whereas biochemical feedback might generate bistability given a constant ongoing Ca2+ influx.
Three tetani were then given to synapse 2. One hour separated the first tetani to synapses 1 and 2. Despite anisomycin, synapse 2 underwent L-LTP.
Some previous models have suggested reactivation may preferentially occur at strong synapses.
For all synapses in the group, the upper bound of the synaptic weight was no longer fixed at 1.0 as in Eq. 5. Instead the bound was given by a maximal value (Wmax) minus the product of an increment (Winc) with the number of strong synapses (W>0.4, corresponding to the upper stable state of W).
If, for a given synapse, no voxels could be found where that synapse was supra-threshold, such synapse was said to be lost.
However, episodic activity with shorter inactive intervals maintained strong synapses.
