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This procedure maximized use of an extensive body of relevant and reliable literature on MTBE with evidence supporting or opposing a given mode of action hypothesis.
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In less abstract terms, reason's self-scrutiny is scrutiny by all those who demand justification for any given mode of thought or action.
Given the mode of action of triptans [2 4], we hypothesized, that differences in BOLD activation between sumatriptan and saline/ASA would be revealed in the trigeminal nuclei.
Given this mode of action of natalizumab and the potential consequence of PML in a subset of treated patients, it has been suggested that natalizumab treatment could result in a state of localized immune suppression in the CNS which could potentially lead to the reactivation of latent viruses [11].
This novel and potentially effective compound may in turn provide a unique therapeutic strategy given its mode of action.
Given the mode of action of DCA and UDCA on cell membranes, it is likely that these two bile acids can act on some of the same signaling pathways.
18 Thus, given its mode of action, TCZ provides a highly specific molecular intervention with which to dissect the role of IL-6 in the modulation of lipid particles and the regulation of other vascular risk factors in patients with chronic inflammation.
Given that the mode of action and metabolites derived from INH have been contentious since its discovery (59, 60), some of the earlier reports utilized dialysis to evaluate release profiles of the drug from NPs (61).
Given this distinct mode of action, we asked if combined CsA and juglone therapy would be additive or synergistic.
Given this known mode of action, genistein has been the subject of numerous studies in experimental animals and humans because of its possible beneficial and adverse health effects due to estrogenic activity [21], [25].
Given the complex mode of action of dynamin, interpretation of the effects of overexpression of the K44A mutant in terms of precise mechanisms is difficult [8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com