Sentence examples for given its role as from inspiring English sources

Given its role as a master regulator of redox metabolism, it is perhaps not surprising that Nrf2 may affect the activity of this organelle.

The Northern Ireland secretary, Theresa Villiers, said the news about Bombardier was "bitterly disappointing" given its role as a large employer in Northern Ireland.

"The public rightly expects all ONS releases to reflect the facts accurately, given its role as a trusted and respected institution.

Targeting TGFβ/Smad signaling is an attractive strategy for several therapeutic applications given its role as a key player in many pathologies, including cancer, autoimmune diseases and fibrosis.

But Mueller, who has spent nearly his entire career working for the Justice Department, seems unlikely to confront the office's conclusion head-on, given its role as the executive branch's foremost legal authority.

By the time of the auto bailouts, Ally was seen as a crucial part of the Obama administration's rescue of G.M. and Chrysler, given its role as a key source of buyer and dealer financing.

Such 'scene-organisation' functions may be performed as early as V2, given its role in long-range grouping, and integration/segmentation of overlapping or occluding surfaces [44], [45].

Although ASPM was part of a signature of 254 genes predictive of metastasis [46], a functional role for this gene in metastatic progression is not obvious given its known role as a spindle protein that regulates brain size with mutations in the gene being associated with microcephaly [47].

Given its central role as a tumor suppressor, it is not surprising that p53 can regulate several aspects of cellular metabolism and thereby counteract many of the metabolic alterations associated with cancer development .

The endoplasmic reticulum stress (ERS) response has also been a recent focus from a cancer therapeutic perspective, given its emerging role as a protective mechanism against chemotherapy-induced cytotoxicity and as a potential initiating step in the development of chemoresistance (reviewed in Schönthal, 2009).

Given its historic role as the centre of Islamic pilgrimage, it is a collection of immigrant communities coming mainly from countries where Muslims face persecution and discrimination at home.