Given its role, it is not surprising, but yet striking, that the spindle assembly checkpoint can delay anaphase in response to a single uncaptured chromosome, exhibiting excellent sensitivity.
Given its role in modulating cell proliferation, it is not surprising that p16 alterations are one of the most common genetic/epigenetic alterations in cancer.
Given its role in Bub1 kinetochore recruitment, it is not surprising that Mps1 inhibition delays the centromeric accumulation of the CPC.
The role of ADAMTS3 in cariogenesis is unknown; however, given its role in tooth development in mouse, it is plausible that this gene affects susceptibility to dental caries.
In the public mind Sky's identification with the cycling team is particularly close, given its role in the project's creation, but it will not be there for ever.
Given its role in KRAS wild-type colorectal cancers, it has also been studied in the first-line setting in advanced BTC phase II trials.
Given its role as a master regulator of redox metabolism, it is perhaps not surprising that Nrf2 may affect the activity of this organelle.
Nor is the European court of human rights, given its role in the Abu Qatada extradition affair.
Schindler said pretrial reform should have been part of the landmark legislation, given its role in sentencing.
Mitochondrial DNA (mtDNA) might be important in hypoxia adaptation given its role in coding core subunits of oxidative phosphorylation.
The Northern Ireland secretary, Theresa Villiers, said the news about Bombardier was "bitterly disappointing" given its role as a large employer in Northern Ireland.
