To do this we rely on the notion of local clustering coefficient, which is defined as the proportion between the number of triangles in which a node is involved, and the total number of triangles in which it could be involved given its degree [77].
Given a JACS J, v ∈ J was called a hub if it satisfied three requirements: (a) the degree of v within the subnetwork J exceeds 7; (b) the degree of v in J is among the five highest in J; (c) the degree of v in J is significantly high given its degree in the whole network (p < 0.05 using hypergeometric distribution).
Finally, it is also interesting to point out that APC2 genes, not considered here given its low degree of similarity, may all derive from a fourth gene with a cullin domain that also emerged before the unikont/bikont split [ 57- 60].
"Germany, given its high degree of openness and specialization, cannot prosper alone," the bank said in its monthly report.
Given its high degree of conservation and similarity to TRE and CRE sites, we first tested its ability to recruit transcription factors in vitro.
While our domain-based identification of a PERK ortholog in L. donovani (Figure 3A) suggested that this pathway was also conserved in Leishmania species, localization of the T. brucei PERK ortholog to the flagellar pocket [15] suggested that PERK in L. donovani, given its high degree of similarity with its trypanosome orthologs (Figures 4) may behave in a similar manner.
Given its high degree of integration into major cell signaling pathways, autophagy represents an attractive target for pharmaceutical manipulation.
Given its high degree of similarity to acetyl-CoA, acetonyl-CoA has been utilized as a general inhibitor of acetyl-CoA utilizing enzymes, including HATs.
Given its high degree of heritability [ 3, 4], a number of studies have examined genetic variation and mammographic density utilising a candidate gene approach focusing primarily on polymorphisms in oestrogen synthesis and metabolising genes with inconclusive results [ 5- 10].
But imagine that this animal is bound by perception, in the sense that at a time t the animal is only able to represent elements of the world it perceives at t. Like a jet engine attached to a tricycle, this hypothetical animal's marvellous recombinatory abilities would rarely be put to use given its low degree of stimulus-independence.
Notable alumni include Liverpudlian composer, Emily Howard, and classical pianist, Stephen Hough. 6) Royal Conservatoire of Scotland, Glasgow – 98 per cent As the third conservatoire to make up the top ten for highest graduate employment, the RCS became the first conservatoire in the country to be given its own degree-awarding powers up to taught Masters level.
