21 This study had the largest patient population and was the only study which clearly gave discontinuation rates secondary to ADRs.
However, given the discontinuation of After Dark, we believe it makes sense for both sides to voluntary terminate the agreement.
The principle reasons given for discontinuation included financial problems, poor marketing and lack of demand.
Given the discontinuation of this microarray the algorithm will be made publically available when the probe set is validated on a new platform.
Sulodexide given after discontinuation of anticoagulant treatment reduced the risk of recurrence in patients with unprovoked venous thromboembolism, with no apparent increase of bleeding risk.
We reviewed the codes given for discontinuation from the study, which are found in appendix G of the CSR, and we made changes in a proportion of cases.
Given that discontinuation nearly exclusively equals evidence of performance improvement in those patients, we further hypothesised that discontinued patients live longer than those who stay on the LCP.
48 Another study of mostly young adults (mean age 32 ± 16.8 years old, oldest subject 75) found levetiracetam had a higher retention rate for patients than TPM; the most important reason given for discontinuation of TPM was cognitive side effects.
Extrapyramidal side effects (tremor, tardive dyskinesia with bradykinesia, and bradykinesia with rigidity) were the reasons given for discontinuation in three patients in a case series of six treated with long-acting risperidone injection.
Golimumab dose escalation occurred in approximately one-quarter of randomised patients and, given low discontinuation rates due to lack of golimumab efficacy, likely reflects a treat-to-target therapeutic approach in patients with residual disease activity.
Constipation occurred in just 9% and rapidly resolved on dose reduction, giving a discontinuation rate due to constipation of just 2%.
