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We found no evidence of a high number of early deaths in an observational study of 1957 patients routinely given atropine before oxygen that might support guidance that oxygen must be given before atropine.
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Results: All patients were given atropine and 1 g loading dose of pralidoxime.
Baboons were sedated with ketamine (10 mg/kg), given atropine (0.025 mg/kg) and intubated.
Mohammad recalls giving atropine injections to dozens of survivors brought into the field hospital that night including, unsuccessfully, his own father.
No CGRP or SP effect on TK activity could be demonstrated after giving atropine.
There is no need to do this before atropine is given, because pinpoint pupils and sweating in a region where these pesticides are common are sufficient to indicate OP/carbamate poisoning and trigger the decision to give atropine.
There is no good evidence that giving atropine to a cyanosed patient causes harm.
Although it is preferable that oxygen is given early to all ill patients, do not delay giving atropine if oxygen is unavailable.
Give 500 1000 ml (10 20 ml/kg) of normal saline over 10 20 min. Three to five minutes after giving atropine, check the five markers of cholinergic poisoning (Table 2).
Currently, we can find no evidence to support the claim that oxygen must be given before atropine.
However, some authors advise that oxygen must be given before atropine due to the risk of inducing ventricular dysrhythmias in hypoxic patients.
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