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Radiotherapy had to be given as a single modality treatment with curative intent for a biopsy proven squamous cell carcinoma of the larynx.
The criteria for a radioresistant tumour was the following: Radiotherapy had to be given as a single modality treatment with curative intent for a biopsy proven squamous cell carcinoma of the larynx.
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The drug is usually given as a single dose.
RRCoDs were given as a single cause in most cases.
Surgery and radiation therapy have been used as a single modality or in combined modality therapy but have resulted in few cures (Hanna and Einhorn 2002).
In recent years, single-dose radiosurgery, normofractionated and hypofractionated stereotactic radiotherapy have been investigated as a single modality or in combination with chemotherapy [ 2- 8].
Given that WP1066 has recently entered clinical trials as a single modality treatment for brain cancer (http://clinicaltrials.gov/show/NCT01904123), these data support the study of its combination with radiotherapy against GBM.
Some authors have reported the clinical applicability of FDG-PET/CT as a single modality in IgG4-related autoimmune pancreatitis [23, 40].
A small study evidenced that the overall sensitivity of WB-DWI as a single modality for the detection of malignant lesions was 81%%.
Although chemotherapy as a single modality has demonstrated limited efficacy, it may improve the result as a concurrent treatment [11].
Allosteric inhibition of Akt may be useful as a single modality in the treatment of these tumors, including those that have become resistant to HER2 inhibitors.
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