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Moreover, it is often possible to delineate chemoresistance mechanisms based on the specific mechanism of action of a given anticancer drug.
A limited dose however will limit the therapeutic index of given anticancer drugs.
These circulating miRNAs are particularly interesting in the context of personalized medicine because correlations between high levels of specific circulating miRNAs and the response to a given anticancer treatment have been observed [ 26, 88, 99].
Importantly, detailed dissection of the molecular characteristics of the biological samples of patients experiencing either a striking response to any given anticancer treatment or a particularly aggressive course of the disease will potentiate our ability to identify biomarkers of sensitivity or resistance to the applied therapeutics.
Researchers have shown a correlation between circulating miRNA expression levels and response to a given anticancer treatment, as in the case of serum miR-21 levels that were higher in hormone-refractory prostate cancer patients whose disease was resistant to docetaxel-based chemotherapy than in patients whose disease was chemosensitive [52].
If objective (and early) prognostic measures of the pharmacodynamic activity for a given anticancer drug can be established, identification of the patients most likely to respond to treatment, in addition to patients with a higher risk of experiencing adverse effects, can be envisioned.
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Evidence from recent publication indicates that marine natural products, especially the secondary metabolites from marine organisms, are potential source and give high yield anticancer drugs than terrestrial sources [ 6, 7].
Given the anticancer activity of the diazapyrenium dications, we might expect that the DAPP2+ dications would also possess anticancer activity, and may be more effective intercalators than the diazapyrenium dications on account of their extended polyaromatic cores.
The groups that were given the anticancer drug received 45 mg/kg for 7 and 14 days, respectively.
Let us denote Πas the true response rate when given some anticancer agent.
In this concern, we found that the incubation of these cells with mixture of the high potent compounds (I, F, G and D) gave high anticancer activity and the anticancer effect was concentration dependent.
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