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Matching on the stratification score leads to more accurate matches because case participants are matched to control participants who have a similar risk of disease given ancestry information.
Instead, given Ancestry.com's roots as a family resource company, its services combine "advanced DNA science with the world's largest online family history resource" to predict your genetic makeup, extend your family history and connect you with other family members.
To do that, we multiplied the proportions of a given ancestry in a given color category by the census proportion of that color category in the specific region, to arrive at ancestry estimation independent of color.
To calculate the total ancestry we simply multiply the proportions of a given ancestry in a given color category by the census proportion of that color category in the specific region to arrive at an ancestry estimation regardless of color.
For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a "total ancestry" estimate.
That is, at a given ancestry value, the fold expansion is equal to the number of folds with an ancestry value less than or equal to the given ancestry value divided by the total number of folds in the functional category.
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The final term in Equation (1), namely the probability of the downstream ancestry given the upstream ancestry and the recombination event between SNPs r and r + 1 is given by the following transition matrix: (5) Note that in the above equation we implicitly assume that s1 = s2, and so the recombination occurs on the chromosome carrying the ancestries t1, t2.
Affected-only study designs require strong prior information on the frequencies of each allele given locus ancestry.
Those with probabilities <0.95 were given 'unassigned' ancestry.
To identify regions that have a significantly higher proportion of a given parental ancestry, we followed published studies (Bryc et al. 2010) considering only regions outside the range defined by the genome mean value for a certain ancestry ± 3SD.
Given desired ancestry proportions α and β, the age n of the point admixture, and the number m of admixed individuals to simulate, we built each admixed chromosome as a composite of chromosomal segments from the source populations, choosing breakpoints via a Poisson process with rate constant n, and sampling blocks at random according to the specified mixture fractions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com